000			02798cam a22003498a 4500
001			2003054715
003			DLC
005			20190729102838.0
008			030523s2004 nju b 001 0 eng
010			_a 2003054715
020			_a0691016364 (cloth : alk. paper)
040			_aDLC _cDLC _dDLC
042			_apcc
043			_an-us-me
049			_aEY8Z
050	0	0	_aQL737.R666 _bR334 2004
082	0	0	_a616/.027333 _221
100	1		_aRader, Karen A. _q(Karen Ann), _d1967-
245	1	0	_aMaking mice / _cKaren A. Rader.
260			_aPrinceton, NJ : _bPrinceton University Press, _c2004.
300			_axviii, 299 p. : _bill. ; _c25 cm.
500			_aOriginally presented as the author's thesis (doctoral)--Indiana University, 1995.
504			_aIncludes bibliographical references (p. [269]-292) and index.
505	0		_aINTRODUCTION: Why Mice? Ch. 1: Mice, Medicine, and Genetics: From Pet Rodents to Research Materials (1900-21) -- Ch. 2: Experiment and Change: Institutionalizing Inbred Mice (1922-30) -- Ch. 3: Mice for Sale: Commodifying Research Animals (1930-33) -- Ch. 4: A New Deal for Mice: Biomedicine as Big Science (1933-40) -- Ch. 5: R X Mouse : JAX Mice in Cancer Research (1938-55) -- Ch. 6: Mouse Genetics as Public Policy: Radiation Risk in Cold War America (1946-56) -- EPILOGUE: Animals and the New Biology: Oncomouse and Beyond.
520			_aPublisher description: Making Mice blends scientific biography, institutional history, and cultural history to show how genetically standardized mice came to play a central role in contemporary American biomedical research. Karen Rader introduces us to mouse "fanciers" who bred mice for different characteristics, to scientific entrepreneurs like geneticist C. C. Little, and to the emerging structures of modern biomedical research centered around the National Institutes of Health. Throughout Making Mice, Rader explains how the story of mouse research illuminates our understanding of key issues in the history of science such as the role of model organisms in furthering scientific thought. Ultimately, genetically standardized mice became icons of standardization in biomedicine by successfully negotiating the tension between the natural and the man-made in experimental practice. This book will become a landmark work for its understanding of the cultural and institutional origins of modern biomedical research. It will appeal not only to historians of science but also to biologists and medical researchers. Karen Rader is Marilyn Simpson Chair of Science and Society at Sarah Lawrence College.
650		0	_aMice as laboratory animals _xHistory.
610	2	0	_aJackson Laboratory (Bar Harbor, Me.)
948			_au171293
949			_hEY8Z _i33039000727874
596			_a1
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999			_c8642 _d8642